An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 174/2

Thomas Jenuwein

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Epigenetic Control by Histone Methylation

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The structure and function of mammalian heterochromatin has been a major focus of our laboratory, since our discovery of the first histone lysine methyltransferases (KMTs). Currently, our research focuses on the epigenetic profiling of large chromosomal regions, analyzing the role of non-coding RNAs in heterochromatin formation, identifying all components for mammalian heterochromatin and dissecting signalling pathways to chromatin. As associated member we see many natural synergies with the research conducted within EpiGeneSys. In particular, we are convinced that our lines of research will significantly contribute to WP2 (Dynamics of Epigenetic Regulators) and WP4 (Signalling to the epigenome). In addition, we are also highly committed to support the training program for young scientists as well as the public education mission of EpiGeneSys.

Latest publications

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.

25487737 – 2014-12-10
Nat Commun 2014 Dec 9;5:5691
Sone K, Piao L, Nakakido M, Ueda K, Jenuwein T, Nakamura Y, Hamamoto R

Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8.

25139859 – 2014-08-21
Development 2014 Sep;141(17):3431-6
Fujimura Y, Isono K, Vidal M, Endoh M, Kajita H, Mizutani-Koseki Y, Takihara Y, van Lohuizen M, Otte A, Jenuwein T, Deschamps J, Koseki H

Suv39h-Dependent H3K9me3 Marks Intact Retrotransposons and Silences LINE Elements in Mouse Embryonic Stem Cells.

24981170 – 2014-07-02
Mol Cell 2014 Jun 26;
Bulut-Karslioglu A, De La Rosa-Velázquez IA, Ramirez F, Barenboim M, Onishi-Seebacher M, Arand J, Galán C, Winter GE, Engist B, Gerle B, O’Sullivan RJ, Martens JH, Walter J, Manke T, Lachner M, Jenuwein TView all their publications


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