An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 175/2

Institute of Molecular Genetics (IGMM), CNRS and University of Montpellier, France

Genomic Imprinting and Development

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Our team is interested in genomic imprinting in mammals and how this epigenetic phenomenon contributes to development and disease. Our research explores the importance of histone lysine and arginine methylation and non-coding RNAs (ncRNAs) in the process of genomic imprinting. We investigate the establishment of DNA methylation imprints in male germ cells, how these heritable marks mediate imprinted gene expression during embryonic development, and how perturbation of imprinting mechanisms could contribute to disease. Our EpiGeneSys projects use the mouse as a model system and address three main questions: i) the role of histone methylation and ncRNAs in the establishment of DNA methylation imprints in germ cells, ii) histone methylation and the somatic maintenance of imprints, and iii) ncRNA-mediated control of imprinted gene domains during development.

Post-doctoral researchers:

  • Michael Girardot, PhD
  • Ryutaro Hirasawa, PhD
  • Satya Kota, PhD
  • David Lleres, PhD, Staff Scientist
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Latest publications

EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos.

26576615 – 2015-11-19
Genome Res 2015 Nov 17;
Auclair G, Borgel J, Sanz LA, Vallet J, Guibert S, Dumas M, Cavelier P, Girardot M, Forné T, Feil R, Weber M

Long noncoding RNAs in human disease: emerging mechanisms and therapeutic strategies.

26418705 – 2015-09-30
Epigenomics 2015 Sep 29;
Lalevée S, Feil R

Chromatin mechanisms in the developmental control of imprinted gene expression.

25908531 – 2015-04-25
Int J Biochem Cell Biol 2015 Apr 20;
Sanli I, Feil RView all their publications