Advancing Epigenetics Towards Systems Biology

Robert Feil

Institute of Molecular Genetics (IGMM), CNRS and University of Montpellier, France

Genomic Imprinting and Development

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Our team is interested in genomic imprinting in mammals and how this epigenetic phenomenon contributes to development and disease. Our research explores the importance of histone lysine and arginine methylation and non-coding RNAs (ncRNAs) in the process of genomic imprinting. We investigate the establishment of DNA methylation imprints in male germ cells, how these heritable marks mediate imprinted gene expression during embryonic development, and how perturbation of imprinting mechanisms could contribute to disease. Our EpiGeneSys projects use the mouse as a model system and address three main questions: i) the role of histone methylation and ncRNAs in the establishment of DNA methylation imprints in germ cells, ii) histone methylation and the somatic maintenance of imprints, and iii) ncRNA-mediated control of imprinted gene domains during development.

Post-doctoral researchers:

  • Michael Girardot, PhD
  • Ryutaro Hirasawa, PhD
  • Satya Kota, PhD
  • David Lleres, PhD, Staff Scientist

Latest publications

In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression.

27095822 - 2016-04-21
Cereb Cortex 2016 Apr 19;

Bouschet T, Dubois E, Reynès C, Kota SK, Rialle S, Maupetit-Méhouas S, Pezet M, Le Digarcher A, Nidelet S, Demolombe V, Cavelier P, Meusnier C, Maurizy C, Sabatier R, Feil R, Arnaud P, Journot L, Varrault A

The cell proliferation antigen Ki-67 organises heterochromatin.

26949251 - 2016-03-08
Elife 2016 Mar 7;5

Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, Gerbe F, Prieto S, Krasinska L, David A, Eguren M, Birling MC, Urbach S, Hem S, Déjardin J, Malumbres M, Jay P, Dulic V, Lafontaine DL, Feil RP, Fisher D

Regulatory links between imprinted genes: evolutionary predictions and consequences.

26842569 - 2016-02-05
Proc Biol Sci 2016 Feb 10;283(1824)

Patten MM, Cowley M, Oakey RJ, Feil R

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