Instituto de Biologia Molecular de Barcelona-CSIC and Institute for Research in Biomedicine (IRB Barcelona), Spain

Chromatin structure and function

Web Page

ferran azorinferran azorin group

The last few years have witnessed an explosion of information concerning our understanding of the epigenetic factors, and mechanisms, that regulate chromatin structure and function. Many fundamental questions remain, however, unanswered. Our research addresses the epigenetic mechanisms that regulate three specific processes: centromere/kinetochore assembly, transcription initiation and higher-order chromatin organisation. Below is a brief description of our main goals on each one of these topics.

(a) Centromere/kinetochore assembly and function
(a.1) Characterisation of the molecular mechanisms that determine specific centromeric localisation of the histone H3 variant CenH3/CENP-A and, in particular, the role of CenH3/CENP-A proteolysis.
(a.2) Analysis of the molecular interactions that lead to kinetochore assembly.

(b) Transcription initiation
Analysis of the mechanism(s) of action of two novel epigenetic factors, dKDM5/LID and HP1c/WOC/ROW, which are involved in transcription initiation.

(c) Higher-order chromatin organisation
(c.1) Analysis of the contribution of histone H1 to the epigenetic regulation of chromatin structure and function.
(c.2) Analysis of the contribution of CENP-Bs to higher-order chromatin organisation.

Mònica Torras-Llort, postdoc
Olga Moreno-Moreno, postdoc
Sonia Medina-Giró, PhD student
Tomás Morán, postdoc
Roman Kessler, PhD student
Anne Daulny, postdoc
Eva Mejía-Ramírez, postdoc
Carles Bonet-Costa, postdoc
Salva Pérez-Montero, PhD student
Aleix Bayona, PhD student

Latest publications

The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development.

26183107 - 2015-07-18
Dev Biol 2015 Sep 15;405(2):260-8
Morán T, Bernués J, Azorín F

Germline-specific H1 variants: the "sexy" linker histones.

25921218 - 2015-04-30
Chromosoma 2015 Apr 29;
Pérez-Montero S, Carbonell A, Azorín F

dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes.

25916810 - 2015-04-29
Nat Commun 2015 Apr 28;6:7049
Kessler R, Tisserand J, Font-Burgada J, Reina O, Coch L, Attolini CS, Garcia-Bassets I, Azorín F

View all their publications

News flash

Missing link in epigenetics could explain conundrum of disease inheritance

08-07-2016 - All News

The process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of...

Epigenetic switch for obesity

08-02-2016 - All News

Obesity can sometimes be shut down It is well known that a predisposition to adiposity lies in our genes. A new study by researchers at the Max Planck Institute of Immunobiology...

Latest opportunities

Post-doc position in chromatin biochemistry - Tuesday, 25 October 2016
Postdoc Position in Bioinformatics - Monday, 24 October 2016
Master student - Friday, 21 October 2016
Linker Histone H1 in Chromatin Regulation - Tuesday, 18 October 2016