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Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Denmark

Chromatin replication

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anja grothanja groth group

Research the Groth laboratory focus on how chromatin is replicated to ensure faithful transmission of both genetic and epigenetic information during cell division. We are currently taking complementary genomic and proteomic approaches to identify new molecular mechanisms orchestrating chromatin replication. We have established a high-throughput siRNA screen for new factors implicated in chromatin replication and we are currently validating the first hits. This work involves an ESR from the FP7 Marie Curie ITN Nucleosome4D. From the proteomic angle, we are developing a novel technology to profile newly synthesized chromatin and follow its dynamic changes though the cell cycle. Our goal is to obtain quantitative proteomic data on chromatin restoration and specific changes arising in response to replication damage. We are interested in working together with system biologists within the Epigenesys network to model the process of chromatin replication, and in particular how perturbation of replication would challenge epigenetic integrity.

Latest publications

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.

26711499 - 2015-12-30
J Cell Biol 2016 Jan 4;212(1):63-75
Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N

BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylation.

26620551 - 2015-12-02
EMBO J 2015 Nov 30;
Feng Y, Vlassis A, Roques C, Lalonde ME, González-Aguilera C, Lambert JP, Lee SB, Zhao X, Alabert C, Johansen JV, Paquet E, Yang XJ, Gingras AC, Côté J, Groth A

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.

26167883 - 2015-07-15
Nat Struct Mol Biol 2015 Aug;22(8):618-26
Huang H, Strømme CB, Saredi G, Hödl M, Strandsby A, González-Aguilera C, Chen S, Groth A, Patel DJ

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News flash

Epigenetic switch for obesity

08-02-2016 - All News

Obesity can sometimes be shut down It is well known that a predisposition to adiposity lies in our genes. A new study by researchers at the Max Planck Institute of Immunobiology...

EpiGeneSys in the News

19-02-2015 - All News

Today special issue of Nature about the main findings of the NIH Roadmap Epigenomics Program, the aim of which was to systematically characterize epigenomic landscapes in primary human tissues and...