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Anja Groth

Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Denmark

Chromatin replication

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anja grothanja groth group

Research the Groth laboratory focus on how chromatin is replicated to ensure faithful transmission of both genetic and epigenetic information during cell division. We are currently taking complementary genomic and proteomic approaches to identify new molecular mechanisms orchestrating chromatin replication. We have established a high-throughput siRNA screen for new factors implicated in chromatin replication and we are currently validating the first hits. This work involves an ESR from the FP7 Marie Curie ITN Nucleosome4D. From the proteomic angle, we are developing a novel technology to profile newly synthesized chromatin and follow its dynamic changes though the cell cycle. Our goal is to obtain quantitative proteomic data on chromatin restoration and specific changes arising in response to replication damage. We are interested in working together with system biologists within the Epigenesys network to model the process of chromatin replication, and in particular how perturbation of replication would challenge epigenetic integrity.

Latest publications

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.

24598821 - 2014-03-07
Nat Commun 2014 Mar 6;5:3394
Klimovskaia IM, Young C, Strømme CB, Menard P, Jasencakova Z, Mejlvang J, Ask K, Ploug M, Nielsen ML, Jensen ON, Groth A

Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.

24561620 - 2014-02-25
Nat Cell Biol 2014 Feb 23;
Alabert C, Bukowski-Wills JC, Lee SB, Kustatscher G, Nakamura K, de Lima Alves F, Menard P, Mejlvang J, Rappsilber J, Groth A

New histone supply regulates replication fork speed and PCNA unloading.

24379417 - 2014-01-01
J Cell Biol 2014 Jan 6;204(1):29-43
Mejlvang J, Feng Y, Alabert C, Neelsen KJ, Jasencakova Z, Zhao X, Lees M, Sandelin A, Pasero P, Lopes M, Groth A

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