YOU ARE HERE PUBLICSCIENTIST WEBSITE

Anja Groth

Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Denmark

Chromatin replication

Web Page

anja grothanja groth group

Research the Groth laboratory focus on how chromatin is replicated to ensure faithful transmission of both genetic and epigenetic information during cell division. We are currently taking complementary genomic and proteomic approaches to identify new molecular mechanisms orchestrating chromatin replication. We have established a high-throughput siRNA screen for new factors implicated in chromatin replication and we are currently validating the first hits. This work involves an ESR from the FP7 Marie Curie ITN Nucleosome4D. From the proteomic angle, we are developing a novel technology to profile newly synthesized chromatin and follow its dynamic changes though the cell cycle. Our goal is to obtain quantitative proteomic data on chromatin restoration and specific changes arising in response to replication damage. We are interested in working together with system biologists within the Epigenesys network to model the process of chromatin replication, and in particular how perturbation of replication would challenge epigenetic integrity.

Latest publications

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control.

25817432 - 2015-03-31
Nat Commun 2015 Mar 30;6:6533
Gallina I, Colding C, Henriksen P, Beli P, Nakamura K, Offman J, Mathiasen DP, Silva S, Hoffmann E, Groth A, Choudhary C, Lisby M

Two distinct modes for propagation of histone PTMs across the cell cycle.

25792596 - 2015-03-21
Genes Dev 2015 Mar 15;29(6):585-90
Alabert C, Barth TK, Reverón-Gómez N, Sidoli S, Schmidt A, Jensen ON, Imhof A, Groth A

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.

24598821 - 2014-03-07
Nat Commun 2014 Mar 6;5:3394
Klimovskaia IM, Young C, Strømme CB, Menard P, Jasencakova Z, Mejlvang J, Ask K, Ploug M, Nielsen ML, Jensen ON, Groth A

View all their publications

News flash

  • 1
  • 2
  • 3
Prev Next

EpiGeneSys in the News

19-02-2015 - All News

Today special issue of Nature about the main findings of the NIH Roadmap Epigenomics Program, the aim of which was to systematically characterize epigenomic landscapes in primary human tissues and...

Karolinska Research Lectures : Wolf Reik

07-01-2015 - Science videos

Karolinska Research Lectures : Wolf Reik

"Epigenetic reprogramming in mammalian development" Wolf Reik, EpigeneSys member and at the head of the Epigenetics Programme, in the Babraham Institute in Cambridge gave a lecture the 16th of Ocktober 2014...

EpiGeneScapes

25-11-2014 - All News

EpiGeneScapes

An exhibition exploring epigenetics Featuring works by: Paul Liam Harrison Jo Milne Mhairi Towler Opening: Wednesday 26 November, at 7.30pmExhibition: 27 November –13 December 2014Espai Barra de Ferro,Barra de Ferro 2, 08003 Barcelona EpiGeneScapes presents the...