An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 103

Department of Biochemistry, Oxford University

Chromatin remodeling and gene regulation in simple eukaryotes

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The Mellor group is interested in how the action of chromatin modifying enzymes influences the yeast metabolic cycle, managing the balance between growth and longevity. Maintaining this balance is critical for healthy ageing at the cellular and organismal level. One aim is to understand how switches in the composition of the SAGA complex, particularly Spt7, influences the activities associated with the complex. The group will combine experimental analysis and iterative modelling to describe how the complex changes as growth rate changes and in response to nutrient regulated signal transduction pathways (TORC1 and AMPK) and extend this work into worms and mammals.

PhDs and Postdocs involved in research on EpiGeneSys projects:

  • Dr Ivan Boubriak
  • Mr Struan Murray
  • Mr Harry Fischl
  • Ms Karolina Chiocan
  • Dr Francoise Howe

Latest publications

Sense and antisense transcription are associated with distinct chromatin architectures across genes.

26130720 – 2015-07-02
Nucleic Acids Res 2015 Jun 29;
Murray SC, Haenni S, Howe FS, Fischl H, Chocian K, Nair A, Mellor J

Prednisolone or pentoxifylline for alcoholic hepatitis.

25901427 – 2015-04-23
N Engl J Med 2015 Apr 23;372(17):1619-28
Thursz MR, Richardson P, Allison M, Austin A, Bowers M, Day CP, Downs N, Gleeson D, MacGilchrist A, Grant A, Hood S, Masson S, McCune A, Mellor J, O'Grady J, Patch D, Ratcliffe I, Roderick P, Stanton L, Vergis N, Wright M, Ryder S, Forrest EH, STOPAH Trial

Transcription mediated insulation and interference direct gene cluster expression switches.

25407679 – 2014-11-20
Elife 2014 Nov 19;3
Nguyen T, Fischl H, Howe FS, Woloszczuk R, Serra Barros A, Xu Z, Brown D, Murray SC, Haenni S, Halstead JM, O'Connor L, Shipkovenska G, Steinmeetz LM, Mellor J

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