An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 90

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

X chromosomal regulation

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Over the last decade, the focus of the Akhtar laboratory has been to study the chromatin and epigenetic mechanisms underlying X-chromosome specific gene regulation using Drosophila dosage compensation as a model system. In Drosophila, dosage compensation is achieved by hyperactivation of the single X chromosome in males in comparison to the two female X chromosomes. They study how the dosage compensation complex, composed of RNA and proteins (The Male Specific Lethal (MSL) complex) gets targeted to the X chromosome and modulates transcriptional output. They are also interested in studying how nuclear organization influences X-chromosomal regulation.

People involved in the lab:

  • Thomas Conrad, postdoc
  • Thomas Lingg, PhD student

Latest publications

An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis.

26243146 – 2015-08-06
Nat Commun 2015 Aug 5;6:7889
Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A

The MSL complex: juggling RNA-protein interactions for dosage compensation and beyond.

25900149 – 2015-04-23
Curr Opin Genet Dev 2015 Apr;31:1-11
Keller CI, Akhtar A

Considerations when investigating lncRNA function in vivo.

25124674 – 2014-08-16
Elife 2014 Aug 14;3:e03058
Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, Higgs DR, Miska EA, Ponting CPView all their publications