An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 155

Nuclear Dynamics – Institut Curie/CNRS UMR 3664, Paris, France

Organisation of Heterochromatin Domains

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The Almouzni lab's major scientific objective will be to gain data enabling researchers to model nucleosome assembly with distinct variants and organisation of heterochromatin domains, to assess their plasticity/stability throughout the cell cycle and when challenged under various perturbations. For this, the Almouzni lab will use biochemical and cellular assays involving protein complexes (such as recombinant histone chaperones, histone H3 variants, HP1, epitope tagged in vivo) to study the dynamics and modifications of histone H3 variants and heterochromatin proteins during the cell cycle.

PhD students: Post-docs:
Emmanuelle SZENKER
Paolo BEUZER
Kelly ROMEO
Dan FILIPESCU
Salomé ADAM
FR
IT
FR
RO
FR
Ekaterina BOYARCHUK
Miguel CASANOVA
Zachary GURARD-LEVIN
Sebastian MÜLLER
Rocio MONTES DE OCA
Lisa PRENDERGAST
Gaston SORIA
Adam WOOLFE
RU
PT
USA
DE
MX
IE
AR
UK

 

Latest publications

Chromatin dynamics after DNA damage: The legacy of the access-repair-restore model.

26429064 – 2015-10-03
DNA Repair (Amst) 2015 Sep 15;
Polo SE, Almouzni G

MCM2 binding to histones H3-H4 and ASF1 supports a tetramer-to-dimer model for histone inheritance at the replication fork.

26243657 – 2015-08-06
Nat Struct Mol Biol 2015 Aug 5;22(8):587-9
Clément C, Almouzni G

HJURP Involvement in De Novo CenH3(CENP-A) and CENP-C Recruitment.

25843710 – 2015-04-07
Cell Rep 2015 Apr 7;11(1):22-32
Tachiwana H, Müller S, Blümer J, Klare K, Musacchio A, Almouzni GView all their publications