Advancing Epigenetics Towards Systems Biology

Latest Publications


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April 2017

The impact of rare and low-frequency genetic variants in common disease.

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Genome Biol 2017 Apr 27;18(1):77
Bomba L, Walter K, Soranzo N
Group Leader: Nicole Soranzo

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila.

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Nat Genet 2017 Apr 24;
Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova M, Szabo Q, Xuéreb A, Klopp C, Aravin A, Paro R, Bantignies F, Cavalli G
Group Leader: Renato Paro, Giacomo Cavalli

Multi-tissue DNA methylation age predictor in mouse.

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Genome Biol 2017 Apr 11;18(1):68
Stubbs TM, Bonder MJ, Stark AK, Krueger F, BI Ageing Clock Team., von Meyenn F, Stegle O, Reik W
Group Leader: Wolf Reik
March 2017

Chromatin binding and silencing: Two roles of the same protein Lem2.

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Microb Cell 2016 Apr 4;3(4):185-188
Barrales RR, Braun S
Group Leader: Sigurd Braun

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism.

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Genome Biol 2017 Mar 28;18(1):56
Hahn O, Grönke S, Stubbs TM, Ficz G, Hendrich O, Krueger F, Andrews S, Zhang Q, Wakelam MJ, Beyer A, Reik W, Partridge L
Group Leader: Wolf Reik

SC3: consensus clustering of single-cell RNA-seq data.

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Nat Methods 2017 May;14(5):483-486
Kiselev VY, Kirschner K, Schaub MT, Andrews T, Yiu A, Chandra T, Natarajan KN, Reik W, Barahona M, Green AR, Hemberg M
Group Leader: Wolf Reik

DNA methylation homeostasis in human and mouse development.

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Curr Opin Genet Dev 2017 Mar 2;43:101-109
Iurlaro M, von Meyenn F, Reik W
Group Leader: Wolf Reik

Aging yeast gain a competitive advantage on non-optimal carbon sources.

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Aging Cell 2017 Mar 1;
Frenk S, Pizza G, Walker RV, Houseley J
Group Leader: Jonathan Houseley
February 2017

Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling.

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Elife 2017 Feb 13;6
Coda DM, Gaarenstroom T, East P, Patel H, Miller DS, Lobley A, Matthews N, Stewart A, Hill CS
Group Leader: Caroline Hill

More to cohesin than meets the eye: complex diversity for fine-tuning of function.

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Curr Opin Genet Dev 2017 Feb 9;43:93-100
Pezic D, Weeks SL, Hadjur S
Group Leader: Suzana Hadjur

Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).

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Nat Protoc 2017 Mar;12(3):534-547
Clark SJ, Smallwood SA, Lee HJ, Krueger F, Reik W, Kelsey G
Group Leader: Gavin Kelsey, Wolf Reik

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

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Cell Rep 2017 Jan 31;18(5):1079-1089
Milagre I, Stubbs TM, King MR, Spindel J, Santos F, Krueger F, Bachman M, Segonds-Pichon A, Balasubramanian S, Andrews SR, Dean W, Reik W
Group Leader: Wolf Reik

Chromatin dynamics during the cell cycle at centromeres.

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Nat Rev Genet 2017 Mar;18(3):192-208
Müller S, Almouzni G
Group Leader: Genevieve Almouzni
January 2017

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

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Genome Biol 2017 Jan 26;18(1):18
Ecker S, Chen L, Pancaldi V, Bagger FO, Fernández JM, Carrillo de Santa Pau E, Juan D, Mann AL, Watt S, Casale FP, Sidiropoulos N, Rapin N, Merkel A, BLUEPRINT Consortium., Stunnenberg HG, Stegle O, Frontini M, Downes K, Pastinen T, Kuijpers TW, Rico D, Valencia A, Beck S, Soranzo N, Paul DS
Group Leader: Nicole Soranzo, Stephan Beck, Alfonso Valencia, Henk Stunnenberg

sNASP and ASF1A function through both competitive and compatible modes of histone binding.

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Nucleic Acids Res 2017 Jan 25;45(2):643-656
Bowman A, Koide A, Goodman JS, Colling ME, Zinne D, Koide S, Ladurner AG
Group Leader: Andreas Ladurner