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Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Rhee HS, Pugh BF.

Cell. 2011 Dec 9; 147(6):1408-19
Cell link

Findings- Patients display genome-wide methylation defects due to mutation of DNMT1

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Klein CJ, et al. Nat Genet. 2011 Jun;43(6):595-600.
Pubmed link

Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq

Findings-Male Drosophila analysed using single-embryo RNA-seq demonstrate a previously unknown form of dosage compensation for the X chromosome, coined, “transcriptional buffering”, occurring before the canonical dosage compensation complex is switched on.

Noncanonical compensation of zygotic X transcription in early Drosophila melanogaster development revealed through single-embryo RNA-seq. Lott SE. et. al. PLoS Biol. 2011 Feb 8;9(2):e1000590.
Pubmed link

Findings - The low efficiency of reprogramming after nuclear transfer may in part be explained by ectopic Xist expression.

Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer. Inoue K et. al, Science. 2010 Oct 22;330(6003):496-9.
Pubmed link

News flash

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Missing link in epigenetics could explain conundrum of disease inheritance

08-07-2016 - All News

The process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of...

Epigenetic switch for obesity

08-02-2016 - All News

Obesity can sometimes be shut down It is well known that a predisposition to adiposity lies in our genes. A new study by researchers at the Max Planck Institute of Immunobiology...

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