An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

The new Systems Biology Knowledgebase  (KBase) is a collaborative effort designed to accelerate our understanding of microbes, microbial communities, and plants. It will be a community-driven, extensible and scalable open-source software framework and application system. KBase will offer free and open access to data, models and simulations, enabling scientists and researchers to build new knowledge and share their findings.

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The examples are computational neuroscience oriented, but the observations and advice should apply to any scientific computing area. He makes the important point that the lack of reproducibility of many results can seriously damage the field's credibility (cf. "Climategate" in climate science) as well as hindering scientific progress.
(Link to blog explaining the importance of reproducibility)