The Babraham Institute, Cambridge, United Kingdom
Modelling the influence of current epigenetic information on future actions
Histone modification patterns correlate with the transcriptional level of local genes, but clearly contain other information reflecting the history of the cell and affecting its responses to future stimuli. We are using conditioned behaviours of budding yeast to elucidate causes and predictive effects of histone modification. Specifically, we aim to quantify histone modification variations between cells grown in different environments, and model the effect of these epigenetic differences on future behavioural decisions. By doing so, we will derive predictive models for the influence of current epigenetic information on future gene expression patterns.