An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

Foundation for Research & Technology Hellas - Institute of Molecular Biology & Biotechnology

Description

ESR3: “Role of SATB1 in gene networks that define CD4+ cell plasticity”

ESR4: “Defining the SATB1-dependent three dimensional chromatin structure in CD4+ cells”

The project
The objective of research is the study the SATB1-mediated interactome of mouse CD4+ T cells based upon cytokine and transcription factor gene networks in development and disease. Adaptive immune responses rely upon the differentiation of naïve CD4+ cells into different T helper cell lineages. The different CD4+ T cell fates are determined via complex and cross-interactive networks consisted by cytokines and transcription factors. The co-expression of the latter affects the functional capabilities and the flexibility of the different CD4+ T cell subsets. Moreover, the three dimensional organization of the eukaryotic genome and the interplay of specific protein factors in regulating long range interactions between diverse regulatory elements is becoming appreciated as a possible epigenetic mechanism of cell memory and cell lineage specification. The apparent question is how the protein partners regulate the shaping of the genome.

Who we are
The student will complete their PhD with Professor Charalampos Spilianakis (www.spilianakislab.gr) who is an affiliated professor with the Institute of Molecular Biology and Biotechnology (www.imbb.forth.gr) of the Foundation for Research and Technology (www.forth.gr) and the Department of Biology of the University of Crete (www.uoc.gr) in Heraklion, Crete, Greece.

Qualifications

Who we look for:
A highly motivated student with a background in molecular biology, biochemistry and/or immunology or other relevant field with excellent analytical, communication and interpersonal skills. A team player. The applicant should hold a Diploma or Master’s degree in Biology or Biochemistry. Experience in biocomputing analysis will be positively considered. Extensive practical experience through lab rotations and internships are of advantage. Candidates should also meet the eligibility criteria for the programme (see above).

Salary

Living allowance: 2883€ x 36months
Mobility allowance: 600€ x 36months
Family allowance: 250€ x 36months

Application details

Applications should be submitted to Prof. Charalampos Spilianakis (This email address is being protected from spambots. You need JavaScript enabled to view it.) as well as the Chromatin3D project manager (This email address is being protected from spambots. You need JavaScript enabled to view it.). Please indicate “Chromatin3D-ITN PhD application” in the subject line of your e-mail.
http://www.chromatin3d.eu/index.php/vacancies

Relevant web link: http://www.spilianakislab.gr

Starting date: 1st May 2015
Deadline for applications: 31st March 2015