An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

CNRS/IGMM

Description

Two year postdoc position available in the group Chromatin and DNA replication (group leader: Marta Radman-Livaja) at the Institute of Molecular Genetics in Montpellier, France, to work on the role of chromatin in asymmetric cell division of S.Cerevisiae.

Project summary:
This project is funded by the Agence Nationale de la Recherche (ANR).
Asymmetric cell division is a prerequisite for cellular differentiation and stem cell maintenance. Phenotypic transformation during differentiation is a poorly understood epigenetic phenomenon, in which chromatin, as a transcriptional regulator, theoretically plays a role. The underlying assumption that chromatin components segregate asymmetrically in asymmetric divisions has however not been systematically tested. Budding yeast also undergoes asymmetric divisions producing mother and daughter cells. The mother can generate 30-40 daughters during its replicative lifespan, and most of the factors that determine the phenotypic identity of the mother cell are unknown. The high conservation of chromatin components among eukaryotes and the availability of powerful genetic tools make S.Cerevisiae an ideal system for identifying chromatin components involved in asymmetric division and elucidating the underlying molecular mechanisms, using whole genome and single cell approaches.

Qualifications

PhD in Molecular Biology or related field. Candidates with experience in yeast biology, live cell imaging and fluorescence microscopy will be considered first.

Salary

2500€/month (gross)

Application details

Please apply by sending your CV and publication list together with a motivation letter to:
Marta Radman-Livaja - This email address is being protected from spambots. You need JavaScript enabled to view it.

Starting date: 1st April 2015