Imperial College London, MRC Clinical Sciences Centre, London, United Kingdom
Investigation of molecular mechanisms underlying epigenetic reprogramming
Epigenetic reprogramming is connected with erasure of epigenetic information at the level of DNA methylation, histone modifications and also at the level of higher order chromatin structure. The main research focus of our laboratory is elucidation of the molecular processes that underlie such erasure of epigenetic information in the course of epigenetic reprogramming that occurs naturally in vivo during mouse development. While we are focusing on the mechanistic details of the erasure of DNA methylation and genomic imprints; we are particularly interested in interplay between DNA demethylation, chromatin assembly/disassembly and the role of the cellular environment on the reprogramming process.
