Oxygen regulated non-coding RNAs in cardiomyopathy |
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Friday, 31 May 2013 00:06 |
MRC Clinical Sciences Centre / Imperial College LondonDescriptionThe Epigenetic Regulation of Metabolism group investigates the role of oxygen regulated non-coding RNAs in cardiomyopathy, with a specific focus on the impact of these non-coding RNAs on cardiomyocyte metabolism, growth and contractile regulation. The proposed project builds on the observation that functional inactivation of enhancer-transcribed RNAs (eRNA), a subtype of non-coding RNAs, impacts cardiac physiology and pathophysiology. These data indicate a critical requirement for eRNA function in the development and maintenance of pathologic stress-induced cardiac hypertrophy. Based on these findings, a number of projects will be available to study the function and the underlying mechanism through which specific oxygen-regulated eRNAs contribute to the maladaptive reprogramming events associated with the diseased state. These projects aim to expand our current understanding of oxygen-signalling pathways in heart biology and disease and to provide a framework for the development of clinically-relevant eRNA-targeting antisense RNAs strategies for the treatment of human heart disease. We are seeking highly motivated individuals with a PhD (or equivalent) in a relevant field with a strong background in epigenetics, non-coding RNAs or heart biology. Previous experience in relevant techniques (ChIP, RNA-seq, Northerns, Southerns) would be an advantage but is not required to apply. Good communication and interpersonal skills, and ability to work independently are expected. For more information email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it QualificationsYou will have a PhD or equivalent in cell/molecular biology, an outstanding publication record and a commitment to scientific excellence. Salary£30916 - £41674 This post is a Career Development Fellowship to support post-doctoral scientists in early or changed career training and help establish them as a successful research scientist in their chosen field. It is initially a 3-year training and development post, which incorporates both scientific and transferable skills training. Application detailsApplications are handled by the RCUK Shared Services Centre
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