An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

IGBMC, Strasbourg

Description

PhD position - Epigenetic memory in single cells

The research in our group at the IGBMC in Strasbourg focuses on histone modifications and histone variants with a strong interest in the inheritance of specific chromatin states. This is also of high medical relevance since chromatin-modifying enzymes have been found to be mutated in cancer cells and small molecule inhibitors for these enzymes are very effective in clinical trials. For details visit our webpage.

Our research includes biochemical and biophysical approaches as well as various developmental and cell differentiation systems. Used methods cover the whole field of modern cell and molecular biology/biochemistry such as single cells studies, microfluidics, live cell imaging, yeast genetics, protein purification, immunofluorescence, biophysical techniques, in vitro chromatin assays, mouse genetics, ChIP-seq. and generation of antibodies, etc.

This funded PhD position provides an excellent opportunity for a highly motivated candidate to participate in an exciting project. The aim is to investigate how epigenetic memory and chromatin impact on transcriptional regulation in single cells using a novel microfluidics setup. The project is designed to allow the applicant to play a major role in determining its direction and at the same time benefit from intense interactions and the profound epigenetics/chromatin background of the other members of my lab.

The PhD student will profit from the international, dynamic and stimulating environment in the group, the knowledge of the French language is not required.

Qualifications

A research background, with previous lab experience is essential. Candidates should be highly motivated and be able to work in a collaborative manner.

Application details

If you are interested please apply with your CV and 2 reference letters. Please provide also details about your studies and previous work. Starting date autumn 2013.

For further information and application please contact: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
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