An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

INSERM, U1043 - Inserm U1043, Centre of Pathophysiology of Toulouse Purpan, Toulouse, France

Description

Since March 2013, our team is hosted by the Centre of Pathophysiology of Toulouse Purpan (CPTP). We have a strong expertise in studying and dissecting dendritic and T cell functions. We are currently developing a new area of research within the institute, at the interface between Immunology and Epigenetics. In the context of a project financed by the “Fondation pour la Recherche Médicale” and the University of Toulouse, the postdoctoral researcher will dissect the epigenetic mechanisms controlling regulatory T cell (Treg) development and functions. The position is expected to start on or before September 1st, 2013.

Background:
The Treg compartment is comprised of cells that acquire immunomodulatory properties through the expression of the transcription factor Foxp3 either in the thymus (natural Treg) or in peripheral lymphoid organs (inducible Treg). The external stimuli leading to Foxp3 expression and the signalling events that they induced have been extensively characterized over the past decade. The epigenetic landscape of Treg-related genes (e.g. foxp3, clta4, cd25) also starts to be unravelled in both regulatory and conventional T cells and correlations have been drawn between the level of particular epigenetic marks and the regulation of these genes during Treg commitment. Nevertheless, the functional relevance of these marks on Treg differentiation, stability, and functions, and the molecular players involved in their deposition, largely remain to be identified.

Aim of the project:
Our lab has a privileged access to conditional knockout mice in which the expression of key regulators of genome function is restricted to certain T cell populations, or to other cell types involved in the control of T cell biology (e.g. dentritic cells). Combining in vivo models with molecular and cellular approaches (e.g. ChIP, transcriptomics, cellular immunological assays), the successful candidate will determine the molecular effectors involved in the epigenetic regulation of both natural and inducible Treg development and function.

Qualifications

Candidates should be highly motivated and have a good working knowledge of English. They must be able to work within a team, in a collaborative and multidisciplinary research program, and to independently organize their workload. International candidates are encouraged to apply. Prior knowledge and research experience in Epigenetics is mandatory. Additional expertise in Immunology would be beneficial.

Salary

2 years position

€ 26 000 ending on experience

Application details

Please apply by sending your CV and publication list together with a motivation letter and the name of 2 references to:
Olivier Joffre, PhD - This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Closing date: 14th June 2013