Postdoc position in Amsterdam on chromatin dynamics and inheritance |
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Wednesday, 24 April 2013 15:31 |
Netherlands Cancer Institute, AmsterdamDescriptionHistone proteins that package eukaryotic genomes can carry non-genetic or epigenetic information and thus transmit information about genome activity from one cell generation to the next. Errors in such epigenetic mechanisms can lead to cancer but are also promising targets for therapeutic intervention. This project, which is funded by Netherlands Organisation for Scientific Research (NWO-VICI), is aimed at unravelling the principle mechanisms of epigenetic inheritance. Making use of our recently developed technologies to track histone proteins in living cells, we found that histones can be very mobile and are non-randomly inherited. In the current project we will use state of the art histone tracking assays and combine them with novel genetic barcode-sequencing screens and genomics and proteomics methods to determine the mechanisms and function of histone dynamics and inheritance. We will use budding yeast as a discovery platform, taking advantage of the powerful possibilities for genetic engineering and genetic screens. In parallel we will develop assays in mouse and human cells to translate our findings to mammalian biology. The work will be performed at the NKI and together with national and international collaborators. QualificationsWe are seeking a highly motivated post-doc/bio-informatician or PhD student with a master degree (MSc) in (medical) biology, biochemistry, or bioinformatics. The candidate has proven experience in molecular biology and/or computational biology and affinity with both fields is appreciated. We expect our new team members to be creative and interested in basic science and novel technologies. Experience with yeast is not required. Given the collaborative and multidisciplinary nature of the project, good communication skills are essential and fluency in spoken and written English is required. SalaryWe offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction) and housing facilities in the vicinity of the Institute. Application detailsFor further information about the position please contact Dr. Fred van Leeuwen, division of Gene Regulation,
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