An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

Netherlands Cancer Institute, Amsterdam

Description

Histone proteins that package eukaryotic genomes can carry non-genetic or epigenetic information and thus transmit information about genome activity from one cell generation to the next. Errors in such epigenetic mechanisms can lead to cancer but are also promising targets for therapeutic intervention. This project, which is funded by Netherlands Organisation for Scientific Research (NWO-VICI), is aimed at unravelling the principle mechanisms of epigenetic inheritance. Making use of our recently developed technologies to track histone proteins in living cells, we found that histones can be very mobile and are non-randomly inherited. In the current project we will use state of the art histone tracking assays and combine them with novel genetic barcode-sequencing screens and genomics and proteomics methods to determine the mechanisms and function of histone dynamics and inheritance. We will use budding yeast as a discovery platform, taking advantage of the powerful possibilities for genetic engineering and genetic screens. In parallel we will develop assays in mouse and human cells to translate our findings to mammalian biology. The work will be performed at the NKI and together with national and international collaborators.

Qualifications

We are seeking a highly motivated post-doc/bio-informatician or PhD student with a master degree (MSc) in (medical) biology, biochemistry, or bioinformatics. The candidate has proven experience in molecular biology and/or computational biology and affinity with both fields is appreciated. We expect our new team members to be creative and interested in basic science and novel technologies. Experience with yeast is not required. Given the collaborative and multidisciplinary nature of the project, good communication skills are essential and fluency in spoken and written English is required.

Salary

We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, a competitive salary (including possibilities for additional tax-reduction) and housing facilities in the vicinity of the Institute.

The Netherlands Cancer Institute is an independent research institute located in the lively city of Amsterdam. Our Institute covers all major areas of molecular and cellular cancer biology. Together with the Antoni van Leeuwenhoek Hospital it forms a comprehensive cancer center, combining 54 research groups and a hospital under one roof. Work discussions, lectures and seminars are in English and a large number of international post-docs, students and staff members contribute to the stimulating and international atmosphere of our Institute. Amsterdam is a very livable city with many cultural amenities. Our institute is located within a 20 minute tram or bicycle ride from the center of Amsterdam and within 20 minutes from Schiphol airport by car, bus or bicycle.

Application details

For further information about the position please contact Dr. Fred van Leeuwen, division of Gene Regulation, This e-mail address is being protected from spambots. You need JavaScript enabled to view it or check our web site at www.nki.nl.


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