An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

Institute of Human Genetics, CNRS.

Description

Cells, especially germinal stem cells, maintain genomic integrity by averting the propagation of mutations, generated as a consequence of DNA damage. In particular, they must avoid the deleterious effects of autonomously replicating endogenous transposable elements (TEs), which are known to cause insertional mutagenesis. One of the key players of the TE repression is the piRNA-interacting silencing complex (piRISC), consisting of the association of a PIWI-type Argonaute protein with a small single-stranded PIWI-interacting RNA (piRNA).
The applicant will join a group led by Séverine Chambeyron on a project aimed at getting a better understanding of PIWI-piRISC functions in Drosophila ovaries. Indeed, the laboratory has recently started an ambitious project focused on the piRNA-dependent heterochromatin formation on TE sequences in Drosophila. The successful candidate will contribute to this project by developing biochemical approaches to identify specific factors associated with Piwi-piRNA complex on TE sequences.

Qualifications

Expertise in epigenetic and/or non-coding RNA fields is recommended. Skills in bioinformatics will be appreciated. Applicants who have defended their PhD for less than 2 years and are first-authors on papers published or accepted by peer-reviewed international journals will be considered with priority.

Application details

To apply, please submit an electronic application, which should include a cover letter, your CV, and contact information for 2 references by email to:
Séverine Chambeyron - This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Closing Date: 30 September 2013