An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

The overall objective of our team is to determine how chromosome structure and function affect genome stability. Specifically, we aim to understand how chromatin is integrated into the genome stability networks and to decipher the interconnections between chromatin regulators and genome stability factors during repair of DNA damage and DNA replication. Using budding yeast as a model system we approach our question with a combination of yeast functional genomics coupled with bio-computational analysis and biochemical assays. Our goal is to map the functional networks of chromatin in genome stability, providing insight into the dynamic role of chromatin in DNA metabolism and advancing our understanding of the cellular response to DNA damage.

List of people involved:

Laura Roseaulin
Petra Kaferle