Petra Hajkova |
Imperial College London, MRC Clinical Sciences Centre, London, United Kingdom Investigation of molecular mechanisms underlying epigenetic reprogrammingEpigenetic reprogramming is connected with erasure of epigenetic information at the level of DNA methylation, histone modifications and also at the level of higher order chromatin structure. The main research focus of our laboratory is elucidation of the molecular processes that underlie such erasure of epigenetic information in the course of epigenetic reprogramming that occurs naturally in vivo during mouse development. While we are focusing on the mechanistic details of the erasure of DNA methylation and genomic imprints; we are particularly interested in interplay between DNA demethylation, chromatin assembly/disassembly and the role of the cellular environment on the reprogramming process. |
Residing in the physical heart of the cell, the nucleus has now fully shed its once one-dimensional reputation as the repository for genetic information and steady supplier of messages to the cytoplasm. This sea change…
An open call for bilateral Franco-German projects in human epigenomics from the ANR-France has been announced! The deadline to submit a "declaration of intention" is March 29th, 2013. Click here for the announcement (in French).
Edith Heard, named a Chair of the Collège de France in Epigenetics and Cellular Memory will be giving weekly lectures starting in February that, in the tradition of this great institution, are free for anyone to attend. Lectures (in French) are from 16-17:30…
Watch the Nobel Prize winner, Sir John Gurdon, speak about winning the prize and about his revolutionary work on nuclear reprogramming.