An ambitious EC-funded research initiative on epigenetics advancing towards systems biology

We perform integrative analyses of large datasets to investigate human disease, chromatin structure, regulatory mechanisms and molecular evolution in mammals. This can involve statistical analysis of high throughput expression, sequencing and genotyping datasets, and collaborations with small experimental/clinical groups up to international consortia. Particular areas of interest include:

• Promoter activity and chromatin structure: the roles of various facets of chromatin structure in promoter function and evolution.
• Comparative chromatin structure: the extent and modes of divergence in chromatin structure across cell types and over evolutionary time.
• Chromatin structure and complex traits: the relationships between chromatin structure and the genetic architecture of complex traits and human disease.

Lab members (pictured left to right):

• Zenhua Hu - PhD student
• Stuart Aitken - Bioinformatician
• Ben Moore - PhD student
• Colin Semple - PI
• Philippe Gautier - Bioinformatician
• Emily Chambers - PhD student
• Graeme Grimes - Bioinformatician
• James Prendergast - Bioinformatician
• Alida Kindt - PhD student