An ambitious EC-funded research initiative on epigenetics advancing towards systems biology
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Florian Markowetz |
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Cancer Research UK, Cambridge Research Institute, UK Epi-genetic determinants of Estrogen Receptor binding dynamics
We work on a comprehensive quantitative model of ER binding encompassingupstream signalling pathways, protein co-factors and epigenetic marks. Thismodel will lead to a deeper understanding of the determinants and dynamics of a key process in breast cancer. Epigenetic factors like DNA methylationand histone modifications, are key regulators of ER binding dynamics. We investigate in particular surprising cyclical methylation and de-mythlation events observed at estrogen-responsive genes. In the long term, our model could be used to predict the effects of perturbing components of the pathway with drugs and potentially lead to improved combinatorial treatment regimes. |
News flash
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28.03.13
Scientists >> News
Residing in the physical heart of the cell, the nucleus has now fully shed its once one-dimensional reputation as the repository for genetic information and steady supplier of messages to the cytoplasm. This sea change…
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22.01.13
Scientists >> News
An open call for bilateral Franco-German projects in human epigenomics from the ANR-France has been announced! The deadline to submit a "declaration of intention" is March 29th, 2013. Click here for the announcement (in French).
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18.12.12
Scientists >> News
Edith Heard, named a Chair of the Collège de France in Epigenetics and Cellular Memory will be giving weekly lectures starting in February that, in the tradition of this great institution, are free for anyone to attend. Lectures (in French) are from 16-17:30…
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23.10.12
all videos >> Science clips for the public
Watch the Nobel Prize winner, Sir John Gurdon, speak about winning the prize and about his revolutionary work on nuclear reprogramming.
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