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Roger Foo

Genome Institute of Singapore, Singapore

Cardiac Epigenomics

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roger foo

 

A major research focus of our lab is to understand the epigenome of the heart: how the environment, nutrients and metabolism might shape the cardiac epigenome, and equally how changes in the cardiac epigenome bring about changes in the function of the heart. We make use of heart samples from patients with heart failure as well and in vitro and in vivo experimental models of disease, and employ techniques of high-throughput sequencing and integrative genomics in order to map out what happens to the cardiac epigenome in health and disease. Our ultimate aim is to discover novel targets for heart failure therapy.

Lab members:

  • Ana Vujic, PhD
  • Lee Siggens, PhD
  • Lina Cordeddu, PhD
  • Darshan Brahmbhatt, MBBCh, MRCP
 

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