Friedrich Miescher Institute for Biomedical Reearch, Basel, Switzerland
Structural Biology at the Interface of Epigenetics and Genome Stability
My laboratory works on the structure and function of large multi-subunit macromolecular machines involved in genome and epi-genome maintenance. The laboratory focuses on protein complexes involved in DNA repair, telomere-end protection and histone methylation, and their link to chromatin and epi-genetics. We use structural, biophysical and cellular approaches to elucidate central molecular processes on the level of chromatin. Our focus is (i) to reconstitute complex marco-molecular processes, (ii) determine structures and (iii) provide mechanistic insight into their workings. With this approach we aim to define novel biological functions, in an interdisciplinary fashion.
Residing in the physical heart of the cell, the nucleus has now fully shed its once one-dimensional reputation as the repository for genetic information and steady supplier of messages to the cytoplasm. This sea change…
An open call for bilateral Franco-German projects in human epigenomics from the ANR-France has been announced! The deadline to submit a "declaration of intention" is March 29th, 2013. Click here for the announcement (in French).
Edith Heard, named a Chair of the Collège de France in Epigenetics and Cellular Memory will be giving weekly lectures starting in February that, in the tradition of this great institution, are free for anyone to attend. Lectures (in French) are from 16-17:30…
Watch the Nobel Prize winner, Sir John Gurdon, speak about winning the prize and about his revolutionary work on nuclear reprogramming.