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Nicolas Thomä

Friedrich Miescher Institute for Biomedical Reearch, Basel, Switzerland

Structural Biology at the Interface of Epigenetics and Genome Stability

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nicolas thomanicolas thoma group

My laboratory works on the structure and function of large multi-subunit macromolecular machines involved in genome and epi-genome maintenance. The laboratory focuses on protein complexes involved in DNA repair, telomere-end protection and histone methylation, and their link to chromatin and epi-genetics. We use structural, biophysical and cellular approaches to elucidate central molecular processes on the level of chromatin. Our focus is (i) to reconstitute complex marco-molecular processes, (ii)  determine structures and (iii)  provide mechanistic insight into their workings. With this approach we aim to define novel biological functions, in an interdisciplinary fashion.
 

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Postdoc/bioinformatician on integrative analysis of epigenomic data - 28 August 2013
Epigenetic mechanisms in cardiovascular disease - 28 August 2013
Bioinformatician (m/f) - 27 August 2013
Postdoctoral Research Associate - 26 August 2013