Biotech Research & Innovation Centre (BRIC), University of Copenhagen, Denmark
Research the Groth laboratory focus on how chromatin is replicated to ensure faithful transmission of both genetic and epigenetic information during cell division. We are currently taking complementary genomic and proteomic approaches to identify new molecular mechanisms orchestrating chromatin replication. We have established a high-throughput siRNA screen for new factors implicated in chromatin replication and we are currently validating the first hits. This work involves an ESR from the FP7 Marie Curie ITN Nucleosome4D. From the proteomic angle, we are developing a novel technology to profile newly synthesized chromatin and follow its dynamic changes though the cell cycle. Our goal is to obtain quantitative proteomic data on chromatin restoration and specific changes arising in response to replication damage. We are interested in working together with system biologists within the Epigenesys network to model the process of chromatin replication, and in particular how perturbation of replication would challenge epigenetic integrity.
Residing in the physical heart of the cell, the nucleus has now fully shed its once one-dimensional reputation as the repository for genetic information and steady supplier of messages to the cytoplasm. This sea change…
An open call for bilateral Franco-German projects in human epigenomics from the ANR-France has been announced! The deadline to submit a "declaration of intention" is March 29th, 2013. Click here for the announcement (in French).
Edith Heard, named a Chair of the Collège de France in Epigenetics and Cellular Memory will be giving weekly lectures starting in February that, in the tradition of this great institution, are free for anyone to attend. Lectures (in French) are from 16-17:30…
Watch the Nobel Prize winner, Sir John Gurdon, speak about winning the prize and about his revolutionary work on nuclear reprogramming.