Advancing Epigenetics Towards Systems Biology

How were chromosomes discovered?

The discovery of the chromosome was descriptive from the beginning and inseparably interwoven with the discoveries of the cell and the nucleus. All findings became possible only after Leeuwenhoek´s invention of the microscope in 1674. In 1831 Robert Brown described the 'areola' in orchids being constantly detectable in all cells. He called this areola'the nucleus of the cel'.1838 M. J. Schleiden´s incorrect epigenetic theory claimed that a cell-nucleus is created de novo from the fluid of the cell. This served as a classical antithesis to Edouard van Beneden´s 1883 discovery that chromosomes are individual entities. In 1842 Karl Wilhelm von Nägeli discovered subcellular structures that would later became known as chromosomes. He had observed the 'idioplasma', a network of string like bodies which he falsely assumed to form an interlinked network throughout the entire organism. In 1873 Schneider had described the indirect division of the nucleus with a 'Kernfigur'(nuclear figure) and an 'achromatic spindle'. In 1883, Edouard van Beneden found that after fertilization of the germ cells of the nematode Ascaris megalocephala the chromosomes of the male nucleus do not fuse with those of the oocyte nucleus. Therefore, they are distinct entities.This was the empirical foundation of Mendel´s rules, but their connection was found only several years later. Van Beneden did not yet use the word chromsome, which was later coined by Waldyer in 1888. The term reflected the staining behavior of chromosomes after using specific dyes.

Mon, Oct 29th 2018- Wed, Oct 31st 2018

This meeting on plant epigenetics and transposable elements will take place in Angers (France) from the 29th to 31st of October 2018. The main topics of the meeting will be: Epigenetic and genetic me...

Sun, Nov 4th 2018- Wed, Nov 7th 2018

EVO-DEVO has provided deep changes in our understanding of developmental mechanisms and widened the scope of the diversity of solutions found by distinct groups of organisms to control embryogenesis a...

Mon, Nov 5th 2018- Tue, Nov 6th 2018

Cardiology World 2018 to be held at Amsterdam, Netherlands during November 5-6, 2018. This International Heart Conference will bring together world-class cardiovascular researchers, cardiologists, car...

Tue, Nov 6th 2018- Fri, Nov 9th 2018

Course Overview The aim of this course is to prepare and analyze "bisulfite-free" methylome libraries for Illumina sequencing. We will use a novel enzymatic approach, to detect 5-methyl cytosines (5m...

LAST EVENTS

EpiGeneSys Final
Meeting in Paris

Thur. 11 February 2016 - Sat. 13 February 2016

More than 280 scientists attended the fifth Annual Meeting of EpiGeneSys. The conference kicked off with a talk by coordinator Geneviève Almouzni, Director of the Research Center at the Institut Curie, highlighting the achievements of the network over more than five years...

Maison des océans - Paris Read more

PAST EVENTS

The Non-Coding Genome ...

December 3-4 th, 2015

The last training workshop of the EpiGeneSys network

Hotel Mediterraneo - Rome, Italy Read more

Paris / TriRhena Chromatin Club

July 9th, 2015

...exciting talks and network with members of the Chromatin community!

... An EpiGeneSys TAB workshop

June 11st-12nd , 2015

... learn about current approaches to single cell epigenetics and to meet up and network with...

Montpellier, FranceRead more

Latest publications

2017-06-27

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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2017-05-26

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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2017-04-30

The impact of rare and low-frequency genetic variants in common disease.

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