Advancing Epigenetics Towards Systems Biology

How were chromosomes discovered?

The discovery of the chromosome was descriptive from the beginning and inseparably interwoven with the discoveries of the cell and the nucleus. All findings became possible only after Leeuwenhoek´s invention of the microscope in 1674. In 1831 Robert Brown described the 'areola' in orchids being constantly detectable in all cells. He called this areola'the nucleus of the cel'.1838 M. J. Schleiden´s incorrect epigenetic theory claimed that a cell-nucleus is created de novo from the fluid of the cell. This served as a classical antithesis to Edouard van Beneden´s 1883 discovery that chromosomes are individual entities. In 1842 Karl Wilhelm von Nägeli discovered subcellular structures that would later became known as chromosomes. He had observed the 'idioplasma', a network of string like bodies which he falsely assumed to form an interlinked network throughout the entire organism. In 1873 Schneider had described the indirect division of the nucleus with a 'Kernfigur'(nuclear figure) and an 'achromatic spindle'. In 1883, Edouard van Beneden found that after fertilization of the germ cells of the nematode Ascaris megalocephala the chromosomes of the male nucleus do not fuse with those of the oocyte nucleus. Therefore, they are distinct entities.This was the empirical foundation of Mendel´s rules, but their connection was found only several years later. Van Beneden did not yet use the word chromsome, which was later coined by Waldyer in 1888. The term reflected the staining behavior of chromosomes after using specific dyes.

Mon, Jun 10th 2019- Tue, Jun 11th 2019

Following the success of the previous conferences, we are excited to announce that “7th International Conference on Hypertension & Healthcare” will be held during June 10-11, 2019 at the most beautif...

Mon, Jun 17th 2019- Wed, Jun 19th 2019

Being successful in the previous 3 conferences in the series, Cardiologists 2016 in Berlin, Germany, Cardiologists 2017 in Paris, France and Cardiologists 2018 in Barcelona, Spain, this year we are mo...

Mon, Jun 17th 2019- Tue, Jun 18th 2019

RNA modifications are ubiquitous in biology and present in all classes of cellular RNAs. Recent studies have shown that RNA modifications are critical to the processing and metabolism of different RNA...

Mon, Aug 12th 2019- Tue, Aug 13th 2019

Asia Chemical Engineering 2019 welcomes all attendees, presenters, and exhibitors from all over the world to Auckland, New Zealand. We are delighted to invite you all to attend the “ 7th Asia Pacific ...

  • Naumi Hotel Auckland Airport, 153 Kirkbride Rd, Mangere, Auckland 2022, New Zealand
  • Organizer

LAST EVENTS

EpiGeneSys Final
Meeting in Paris

Thur. 11 February 2016 - Sat. 13 February 2016

More than 280 scientists attended the fifth Annual Meeting of EpiGeneSys. The conference kicked off with a talk by coordinator Geneviève Almouzni, Director of the Research Center at the Institut Curie, highlighting the achievements of the network over more than five years...

Maison des océans - Paris Read more

PAST EVENTS

The Non-Coding Genome ...

December 3-4 th, 2015

The last training workshop of the EpiGeneSys network

Hotel Mediterraneo - Rome, Italy Read more

Paris / TriRhena Chromatin Club

July 9th, 2015

...exciting talks and network with members of the Chromatin community!

... An EpiGeneSys TAB workshop

June 11st-12nd , 2015

... learn about current approaches to single cell epigenetics and to meet up and network with...

Montpellier, FranceRead more

Latest publications

2017-06-27

The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.

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2017-05-26

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

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2017-04-30

The impact of rare and low-frequency genetic variants in common disease.

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