The discovery of the chromosome was descriptive from the beginning and inseparably interwoven with the discoveries of the cell and the nucleus. All findings became possible only after Leeuwenhoek´s invention of the microscope in 1674. In 1831 Robert Brown described the 'areola' in orchids being constantly detectable in all cells. He called this areola'the nucleus of the cel'.1838 M. J. Schleiden´s incorrect epigenetic theory claimed that a cell-nucleus is created de novo from the fluid of the cell. This served as a classical antithesis to Edouard van Beneden´s 1883 discovery that chromosomes are individual entities. In 1842 Karl Wilhelm von Nägeli discovered subcellular structures that would later became known as chromosomes. He had observed the 'idioplasma', a network of string like bodies which he falsely assumed to form an interlinked network throughout the entire organism. In 1873 Schneider had described the indirect division of the nucleus with a 'Kernfigur'(nuclear figure) and an 'achromatic spindle'. In 1883, Edouard van Beneden found that after fertilization of the germ cells of the nematode Ascaris megalocephala the chromosomes of the male nucleus do not fuse with those of the oocyte nucleus. Therefore, they are distinct entities.This was the empirical foundation of Mendel´s rules, but their connection was found only several years later. Van Beneden did not yet use the word chromsome, which was later coined by Waldyer in 1888. The term reflected the staining behavior of chromosomes after using specific dyes.
EVO-DEVO has provided deep changes in our understanding of developmental mechanisms and widened the scope of the diversity of solutions found by distinct groups of organisms to control embryogenesis a...
- Wiston House Suffolk, UK
Cardiology World 2018 to be held at Amsterdam, Netherlands during November 5-6, 2018. This International Heart Conference will bring together world-class cardiovascular researchers, cardiologists, car...
- Amsterdam, Netherlands
Course Overview The aim of this course is to prepare and analyze "bisulfite-free" methylome libraries for Illumina sequencing. We will use a novel enzymatic approach, to detect 5-methyl cytosines (5m...
- EMBL Heidelberg, Germany
Meeting in Paris
More than 280 scientists attended the fifth Annual Meeting of EpiGeneSys. The conference kicked off with a talk by coordinator Geneviève Almouzni, Director of the Research Center at the Institut Curie, highlighting the achievements of the network over more than five years...
The Non-Coding Genome ...
The last training workshop of the EpiGeneSys network
Paris / TriRhena Chromatin Club
...exciting talks and network with members of the Chromatin community!
... An EpiGeneSys TAB workshop
... learn about current approaches to single cell epigenetics and to meet up and network with...
The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1.Read more
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.Read more
The impact of rare and low-frequency genetic variants in common disease.Read more