Advancing Epigenetics Towards Systems Biology

Study of regulatory mechanisms during embryonic stem cell differentiation and cardiac commitment

Center for Translational Medicine/Temple University

Description

Topic: Transcription and Epigenetic Regulation in Embryonic Stem cells and Cardiac Development
Estaras Lab
Center for Translational Medicine
Lewis Katz School of Medicine
Temple University, Philadelphia, Pennsylvania (US)

A 2-years post-doctoral position is available to start on the first trimester of 2019 at the laboratory of Stem Cells and Cardiac Development headed by Conchi Estaras, PhD.

Our new research laboratory forms part of the Center for Translational Medicine at the Lewis Katz School of Medicine in Temple University (Philadelphia). We are part of a diverse and highly collaborative scientific community encouraging interdisciplinary collaborations between the basic and translational research programs.

In our lab, we focus on identifying the molecular mechanisms that control stem cell differentiation toward specific cardiac lineages. We aim to decipher signaling pathways, transcriptional and epigenetic mechanisms that regulate specific cardiac cell fates. We want to use this knowledge to identify mechanisms and factors important for cardiac cell development and to provide new tools to design stem cell-based strategies for cardiac repair.

Our main models of study are human embryonic stem cells (hESCs) and induced Pluripotent Stem Cells (iPSCs). We use directed differentiation strategies together with cardiac organoids to mimic early cardiac cell development. We apply a wide-range of techniques to obtain a comprehensive panel of the transcriptome and the epigenome of the cells during cardiac cell fate acquisition; from conventional western-blot and qPCR to next-generation sequencing (RNA-seq, GRO-seq, ChIP-seq,ATAC-seq) and single-cell sequencing….

If you want to know more about our projects, contact us! We are seeking for enthusiastic candidates with a MD and/or PhD to join our new lab. We also encourage candidates with experience in one or more of the following areas to apply: stem cells, cardiac development, transcription, epigenetics, bioengineering, genomics and/or bioinformatics.

The position offers salary consistent with NIH guidelines and a competitive benefits package.

To apply, please send your CV, cover letter with your motivation for this position, and names of 2 academic references to This email address is being protected from spambots. You need JavaScript enabled to view it.

Qualifications

PhD or/and MD

Salary

The position offers salary consistent with NIH guidelines and a competitive benefits package.

Application details

Please apply by sending your CV together with a motivation letter and the contact of three references to: This email address is being protected from spambots. You need JavaScript enabled to view it.
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