Advancing Epigenetics Towards Systems Biology

Postdoc and PhD positions in non-coding and epigenome architecture at the University of Zurich

University of Zurich

Description

The group of Raffaella Santoro at the University of Zurich, Switzerland, is recruiting for postdoctoral researchers and PhD students for projects aimed to elucidate how chromatin architecture, epigenetics and non-coding RNAs regulate gene expression and cell fate during development and in disease. Our laboratory combines high-throughput data and molecular and cell biology approaches, including the development of NGS and cell biology based novel methods to identify molecular mechanisms of genome organization and their role in the regulation of gene expression (Graf et al., Nature Cell Biology, 2017; Leone et al., EMBO Reports, 2017; Gu et al., Nature Genetics, 2015; Savic et al. Cell Stem Cell, 2014).
Specifically, the projects aim to determine the molecular mechanisms underlying genome organization in pluripotent embryonic stem cells and during cell differentiation and the role of chromatin remodeling complexes, epigenetic enzymes and long non-coding RNAs in these processes.
We offer:

  • The possibility to work on cutting-edge projects using state-of-the-art technology in a highly motivated research team
  • A stimulating, highly interactive, dynamic, and international research environment
  • Advanced training opportunities
The University of Zurich is the biggest University in Switzerland and one of Europe`s leading research centers. On-site core facilities offer easy access to state-of-the-art technologies in genomics, transcriptomics, epigenomics, proteomics, and advanced imaging.

Qualifications

The project is designed for researchers with an independent, well-structured and goal-oriented working style, an outstanding motivation and initiative, and strong interests in mechanistic molecular research.
Candidates for the postdoc position must have a PhD in biology or a related field, with a proven scientific track record (including at least one first author publication), a strong research background in epigenetics and chromatin, and experience in molecular biology techniques. Experience in ChIP-seq techniques and large-scale (next-generation sequencing) dataset analysis will be considered positively.
Candidates for the PhD position should have excellent or very good diploma/master in (molecular) biology or biochemistry. Experience in chromatin, epigenetic and stem cells as well as an interest in bioinformatics will be also considered positively.
Personal strengths should include social competence, reliability and accuracy. The working language is English. Excellent written and oral communication skills are required.

Salary

Contract details will be negotiated and take into account the track record of the candidate

Application details

Qualified and interested candidates should submit their application including a cover letter describing motivation and how her/his background would best fit this position, CV, and the contact information of at least two references. Please send all documents as a single pdf file via e-mail to This email address is being protected from spambots. You need JavaScript enabled to view it.. These positions are available starting from October 2018. Applications will be considered until the positions are filled.

Relevant web link: https://www.dmmd.uzh.ch/en/research/santoro.html

Starting date: 1st October 2018