IJC, Barcelona, Spain
The team of Marcus Buschbeck at the Josep Carreras Leukaemia Research Institute is looking for motivated postdoctoral researchers that are interested in the intersection between nuclear organization and metabolism or leukemia epigenetics.
Two projects are available:
1) Metabolic plasticity through histone variants.
MacroH2A histone variants are unique in having domains binding metabolites (Posavec Marjanovic, Hurtado-Bagès et al., 2017, NSMB) and regulating 3D chromatin architecture (Kozlowski, Corujo et al., 2018, EMBO Rep, Douet et al., 2017, JCS). We want to test the intriguing speculation that macroH2A histone variants convey metabolic sensitivity to 3D chromatin architecture and thereby link epigenetic plasticity to the metabolic state.
2) Epigenetic alterations of the bone marrow stroma and their role in leukemia.
The cells of the bone marrow stroma provide the niche for hematopoietic stem and progenitor cells. Alterations in the niche contribute to diseases including acute and chronic forms of leukemia and myelodysplastic syndromes (MDS). The fact that no recurrent somatic mutations have been found in the stroma argues that disease-associated alterations are of epigenetic nature. We plan to characterize these epigenetic alterations occurring in the bone marrow stroma focusing on MDS and to functionally evaluate chromatin regulators as potential epigenetic drug targets.
We are open to discuss additional ideas and projects.
You will develop your own research project but also tightly collaborate with a PhD student and other lab members. You will write fellowship applications and manuscripts together with the PI.
- A high level of motivation and interest.
- Experience in chromatin biology and/or leukemia.
- Competitive CV with a track record of publications.
- High level of collaborative and communicative skills.
- Good level of English speaking and writing skills (required). Spanish (helpful).
- International mobility and eligibility for European funding schemes such as MSCA will be considered a major plus.
- Contract details will be negotiated and take into account the track record of the candidate.
- Flexible start date.
Relevant web link: http://www.carrerasresearch.org/en/Chromatin_Metabolism_and_Cell_Fate
Starting date: 15th January 2019
Deadline for applications: 15th October 2018