Josep Carreras Leukaemia Research Institute
We are looking for a motivated postdoc who would be interested to dissect the mechanism of the histone variant macroH2A in chromatin architecture. As a dynamic model system we will use leukemia cells that can be differentiated. We will use chromosome conformation-based methods such as HiChIP and quantitative 4C-seq to identify macroH2A-containing and dependent contacts. We want to understand how these contacts are relevant for gene regulation and how they are regulated by signaling and metabolism. Key findings will be validated in patient samples.
Please check out our previous work on macroH2A’s role in nuclear organization (Douet et al., 2017, JCS) its link with cellular metabolism (Posavec, Hurtado et al., 2017, NSMB) and cellular plasticity (Buschbeck and Hake, 2017, NRMCB).
You will develop your own research project but also tightly collaborate with a PhD student and other lab members. You will write fellowship applications and manuscripts together with the PI.
What we offer
- Incorporation in a multinational and highly collaborative team.
- An exciting and innovative research project.
- Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
- The international network of the Buschbeck lab.
- The stimulating environment of the Barcelona metropolitan area.
- Flexible start date (as soon as suitable for you).
What we need
- A high level of motivation and interest.
- Experience in chromatin biology and/or leukemia.
- Competitive CV with a track record of publications.
- High level of collaborative and communicative skills.
- Good level of English speaking and writing skills (required). Spanish (helpful).
- Eligibility for European funding schemes such as MSCA (eg. international mobility) will be considered a major plus.
Contract details and salary will be negotiated and take into account the track record of the candidate.
Relevant web link: http://www.carrerasresearch.org/en/Chromatin_Metabolism_and_Cell_Fate
Starting date: 1st October 2018
Deadline for applications: 15th June 2018