Advancing Epigenetics Towards Systems Biology

Postdoc position in Chromatin remodeling in germ cells

Friedrich Miescher Institute for Biomedical Research (FMI)

Description

A postdoctoral position is available in the group of Antoine Peters at the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel. The laboratory studies the mechanisms underlying chromatin dynamics, gene regulation and epigenetic inheritance in germ cell development, early embryogenesis and between generations of mice. We take an interdisciplinary approach combining methods from molecular biology, biochemistry, mouse genetics, epigenomics and quantitative imaging.

The formation of mature spermatozoa is the outcome of an extensive morphogenetic process during which chromatin undergoes major changes in its composition and organization that are required for male fertility. Our current research focuses on identifying and characterizing at the molecular level the role of proteins and complexes involved (a) in the removal of nucleosomes and replacement by protamines from most parts of the genome or (b) in the retention of nucleosomes at specific sequence in the genome of developing male germ cells. Building upon established methods of germ cell isolation and genome-wide epigenomic insights, you will apply biochemical and proteomic methods as well as molecular genetic approaches to pursue these research questions.

We are looking for a curious, bright and highly motivated individual who enjoys challenging projects and opportunities for discovery and innovation. Expertise in biochemistry is required while familiarity and genuine interest in any of the following topics is considered a plus: proteomics, chromatin biology, genetics and development. One first author publication is required.

The lab provides an international environment where we value open communication, assuming responsibility and collaborative team spirit. Access to the FMI state-of-the-art research facilities and a very competitive salary are offered.

The FMI is a world-class research institute in basic biomedical science that is affiliated with the University of Basel and the Novartis Institutes for BioMedical Research. Basel is a vibrant city in the center of Europe offering an outstanding scientific environment as well as excellent opportunities for cultural and outdoor activities.

Application details

Applications should be submitted electronically at www.fmi.ch/opening and should include a motivation letter, CV and names and email addresses of minimally two referees.
https://www.fmi.ch/careers/positions/opening/

Relevant web link: https://www.fmi.ch/peters.a