An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 127

MRC Clinical Sciences Centre/Imperial College London

Description

Applications are invited for an ERC-funded post-doctoral research position within the Chromatin Biochemistry Group at the MRC-Clinical Sciences Centre. We are looking for a highly motivated researcher to join our international team.

The Chromatin Biochemistry Group at the MRC-Clinical Sciences Centre is headed by Dr Till Bartke and aims to understand how chromatin is regulated by DNA and histone modifications. We have established a SILAC-linked nucleosome affinity purification technique in order to identify chromatin regulators that can recognise DNA and histone modifications on nucleosomes (Bartke et al., 2010, Cell). We are currently investigating the functions of newly identified chromatin readers and we aim to identify new chromatin-interacting proteins that can recognise chromatin modification signatures that demarcate genomic elements such as promoters, enhancers or heterochromatin. You will have the opportunity to engage in these projects using a variety of biochemical, proteomic and genomic approaches.

We are looking for an enthusiastic individual with clear goals, a proactive and flexible attitude to work, and the will to learn new concepts and technologies. The CSC provides an excellent research environment in an international and interactive atmosphere.

This post is full-time, funded until 30 April 2018 and will be based at the Hammersmith Campus of Imperial College London.

Qualifications

You should have a PhD degree in life sciences or equivalent experience with a strong background in chromatin biology and at least one first-author publication in a peer-reviewed international journal published or in press. You will have solid experience in molecular biology and cell biological techniques. Experience in biochemical methods, in particular expression and purification of proteins, mass-spectrometry or high throughput genomic technologies for epigenetic and gene expression profiling would be an advantage.

Salary

£33,860 – £42,830 per annum

Application details

Please apply by sending your CV and publication list together with a motivation letter. Our preferred method of application is online via our website (please select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed quoting reference number HM2016063.

Alternatively, if you are unable to apply online, please email hmrecr@imperial.ac.uk to request an application form. For informal inquiries please contact Dr Till Bartke (e-mail: till.bartke@csc.mrc.ac.uk).

Relevant web link: http://www.csc.mrc.ac.uk/research-group/chromatin-biochemistry/

Starting date: 1st August 2016
Deadline for applications: 17th July 2016