Advancing Epigenetics Towards Systems Biology

13 PhD positions - ITN ChromDesign Marie Curie Network

CNRS/University of Montpellier

Project Description

The European Innovation Training Network “ChromDesign– Chromatin structure and Design” aims to identify novel features in the three-dimensional structure of genes, the so-called chromatin, which are responsible for the development of cells in health and disease. This will set the base for: i) the development of new diagnostic tools, and ii) the identification of novel therapeutic targets, which have the potential to be exploited to deliver new treatments for diseases like leukemia. Designers and scientists will work closely together to implement original, attractive and efficient ways to communicate the project’s complex scientific concepts to the broader society.

The Project is funded by the European Commission under the MSCA-H2020 Program and brings together researchers in Spain, Denmark, Switzerland, Germany, France, Italy, Belgium and United Kingdom, in the academic and private sector, coordinated by Luciano Di Croce, ICREA professor and principal investigator at the Centre for Genomic Regulation (CRG) in Barcelona. In an open call, ChromDesign currently recruits 13 PhD students in the different laboratories of the network.

Research Projects Overview:

  • Project ESR1: Analysis of PCL family of proteins during differentiation (CRG, Spain)
  • Project ESR2: Analysis of MLL family of proteins in leukemias (CRG, Spain)
  • Project ESR3: Integration of experimental data into a single framework to 3D genomics models (CNAG-CRG, Spain)
  • Project ESR4: Novel therapeutic targets for the treatment of leukemia (UCPH, Denmark)
  • Project ESR5: Design of a science communication toolkit (ELISAVA, Spain)
  • Project ESR6: Simultaneous live-cell imaging of chromosome conformation, enhancer-promoter interactions and transcription in mouse ES cells and differentiated derivatives (FMI, Switzerland)
  • Project ESR7: Comprehensive genomic and computational model for establishment of nuclear compartments and their dependency on chromatin modifiers (HMGU, Germany)
  • Project ESR8: Spatio-temporal organization of histone variants: from nucleosomes to nuclei (CURIE, France)
  • Project ESR9: Progression of 3D genome folding in neurons during ageing (EMBL, Germany)
  • Project ESR10: Detection of abnormal chromatin interaction in patient fibroblasts (MPIMG, Germany)
  • Project ESR11: Role of transcription and Polycomb proteins in 3D genome organisation and cell differentiation (IGH-CNRS, France)
  • Project ESR12: An epigenomic approach to study resistance and recurrence in acute myeloid leukemia (IEO, Italy)
  • Project ESR13: Chromatin topology studies in mouse ES and human leukemia cell lines (DIAGENODE, Belgium)

Eligibility criteria

Applicants may be a national of a Member State, of an Associated Country or of any other third country.

At the time of start of the contract, the candidate will have to hold an academic degree that enables her/him to undertake doctoral studies. Preference is given to applicants with MSc or equivalent degree.

At the time of recruitment by the host organisation, candidates must be in the first four years (full-time equivalent research experience) of their research careers and not yet have been awarded a doctoral degree.

At the time of recruitment by the host organisation, candidates must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation for more than 12 months in the 3 years immediately prior to the reference date.


Marie Curie ITNs provide a highly competitive salary to the ESR, including a competitive monthly living and mobility allowance and (if eligible) a monthly family allowance.

Application details

Funding Notes
Depending on the hosting institute, individual projects start between November 2018 and August 2019.