Advancing Epigenetics Towards Systems Biology

Transcription factor

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Term Definition
Transcription factor
(TF) Protein that regulates the activation of transcription in the eukaryotic nucleus. Transcription factors localise to regions of promoter and enhancer sequence elements either through direct binding to DNA or through binding other DNA-bound proteins. They act by promoting the formation of the preinitiation complex (PIC) that recruits and activates RNA polymerase.
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