Advancing Epigenetics Towards Systems Biology

Telomerase

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Term Definition
Telomerase
An enzyme that adds specific DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' ("three prime") end of DNA strands in the telomere regions at the ends of chromosomes. It counteracts chromosome shortening which is a molcular consequence of the cellular replication machinery of the linear eukaryotic chromosomes. The enzyme is a reverse transcriptase that carries its own RNA template; this RNA is used as a template for eukaryotic DNA replication.
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