Advancing Epigenetics Towards Systems Biology

Polycomb-group proteins

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Term Definition
Polycomb-group proteins
A family of proteins first discovered in fruit flies that can remodel chromatin such that transcription factors cannot bind to promoter sequences in DNA. In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins act antagonistically and interact with chromosomal elements, termed Cellular Memory Modules (CMMs).
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