Advancing Epigenetics Towards Systems Biology

Methylation patterns

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Methylation patterns
The pattern of how particular amino acids are methylated within an array of nucleosomes, e.g. a lysine or arginine can be mono-, bi- or trimethylated deciding about the degree of heterochromatinisation. DNA also becomes directly methylated by DNA methyltransferases. In DNA methylation occurs mainly at CpG sites (where a cytosine is followed by a guanine in the DNA sequence). The pattern of histone or DNA-methylation may alter gene expression and can be a reason for developing cancer
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