Advancing Epigenetics Towards Systems Biology

Locus control region

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Locus control region
(LCR) Defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations.
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