Advancing Epigenetics Towards Systems Biology

Histone methylation

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Term Definition
Histone methylation
Modification of the primary protein sequence of a histone protein by the addition of one, two, or three methyl groups. This modification alters the properties of the nucleosome and affects its interactions with other proteins. Specific kinds of methylation, e.g. methylation of lysine 9 within the histone H3 molecule are associated with inactive chromatin (see heterochromatin) where genes are relatively inactive.
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