DNA repair genes
|DNA repair genes||
DNA repair genes encode enzymes which fix DNA damage. Different repair genes function in homologous recombination or double-strand break (DSB) repair (e.g. RecA, Rad50/SMC complex) encompassing non homologous end joining (NHEJ), break-induced replication (BIR), single strand annealing (SSA) and Synthesis-Dependent Strand Annealing (SDSA). Further, in nucleotide excision repair (NER)(e.g. XPD), in base excision repair (BER)(e.g. TDG-glycosylase), mismatch repair (e.g. msh2), damage reversal (e.g. CPD photolyase), damage tolerance (e.g. Rad6), checkpoint-regulatory genes (e.g. RecQ helicases, Rad17, ATM, PARP), DNA polymerases and others like p53.