Advancing Epigenetics Towards Systems Biology

Centromere

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Term Definition
Centromere
Restricted region of chromosomes to which fibres attach during cell division allowing chromosomes to be pulled to different poles. Normally located centrally, but in some species is found near the end (pericentric), at the end (telocentric) or spread all over the chromosomes (holocentric). Characterised by repetitive non-coding DNA sequences and centromeric heterochromatin. The term kinetochore is sometimes used synonymously but is also defined as the protein structure which assembles on the centromere.
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