Advancing Epigenetics Towards Systems Biology

Agouti gene

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Agouti gene
In mice, the agouti (A) gene controls the deposition of yellow pigment in developing hairs. There are several alleles (sequence variants) some of which are dominant, e.g. lethal yellow (Ay) which results in embryonic lethality if mice inherit 2 copies. Methylation of the agouti gene reduces its expression lowering the quantity of yellow pigment produced without altering the sequence of the gene.
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