Advancing Epigenetics Towards Systems Biology


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Term Definition
Trithorax-group proteins
A family of proteins that remodel chromatin such that transcription factors can bind to promoter sequences in DNA, switching genes on. In Drosophila, the Trithorax-group (trxG) and Polycomb-group (PcG) proteins act antagonistically and interact with chromosomal elements, termed Cellular Memory Modules (CMMs).
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Tumor supressor genes
A class of genes involved in prohibiting the growth of tumors. Examples are p16 and p53, dubbed the 'guardian of the genome'.
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Tyrosine phosphorylation
Tyrosine is one of the building blocks of protein that can be modified by the addition of a chemical tag, in this case, a phosphate group.