Advancing Epigenetics Towards Systems Biology

Glossary

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Term Definition
ICF syndrome
(immunodeficiency, centromeric instability and facial anomalies syndrome) Very rare recessive autosomal disorder. It is characterized by a mutation in the DNA-methyltransferase-3b (Dnmt3b) gene. Characterized by facial anomalies such as low-set ears and enlarged tongue. Individuals with the syndrome have very poor immune response to infectious diseases.
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ICSI
(intracytoplasmic sperm injection) Mechanical procedure that injects a sperm into an egg.
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IGF2/IGF2
Human insulin-like growth factor 2 gene/protein, which binds insulin-like growth factor 2 protein, preventing it from promoting growth. Known to be imprinted in mice, but not humans.
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IGF2r/IGF2r
Mouse insulin-like growth factor 2 receptor gene/protein, which binds insulin-like growth factor 2 protein, preventing it from promoting growth. Known to be imprinted in mice, but not humans.
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Imprinted genes
Alleles that are active or silent depending on whether they are inherited from mum or dad. For example, IGF2 that comes from the mother is silent, whereas the copy you get from your dad is active (made into protein). Abnormal imprinting can cause embryonic lethality.
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Imprinting
The phenomenon whereby a small subset of all the genes in our genome are expressed according to their parent of origin.
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Inner Cell Mass
(ICM) Also called embryoblast. Cells from very early developing embryo, when the embryo is merely a ball of cells.
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IVF
In vitro fertilization: a form of ART, in which egg cells are extracted from ovaries and fertilized with sperm ex vivo. Successful fertilization generate an embryo, which is then implanted into the uterus
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