Sexton T, Yaffe E, Kenigsberg E, Bantignies F, Leblanc B, Hoichman M, Parrinello H, Tanay A, Cavalli G.
Cell. 2012 Jan 18. [Epub ahead of print]
Podcast interview of Giacomo Cavalli and Amos Tanay about their recent publication in Cell.
Copyright: Attribution-Noncommercial-Share Alike 2.0 UK: England : http://creativecommons.org/licenses/by-nc-sa/2.0/uk/
For a brief synopsis of what is covered in the podcast, or if you would like to fast forward to a particular point in the podcast, please use the summary below.
1:09 How the Hi-C approach used in the study was modified in order to capture chromatin contacts on a global scale
6:55 Giacomo and Amos explain some of the key findings of the paper
11:15 Waxing philosophical on why a cell might organize its chromatin in the way described in this study
13:15 How systems biologists (computational biologists) and epigeneticists can learn from each other
14:30 Special insights gained using the global modeling approach taken in this study
16:50 Challenges of processing the data
18:10 Refining the model‹is it ever really done?
19:55 Lessons on how biologists doing wet experiments in epigenetics can begin to make sense of all of the data produced by computational biologists doing the dry work