Keystone Symposia: 3D Genome - Gene Regulation and DiseaseSunday 17 March 2019 - Thursday 21 March 2019
Location : Banff, Alberta, Canada
Scholarship and Discounted Abstract Deadline: November 15, 2018!
Transcription of the eukaryotic genome is not only driven by the cis regulatory elements embedded in the linear DNA sequence but also by the way chromosomes fold in the three-dimensional (3D) nuclear space. Growing evidence has pointed to a key role of the 3D genome architecture in gene regulation and human disease; however, the details of dynamic chromatin organization in different cell types remain opaque. Additionally, how chromatin organization shapes the gene regulatory program and influence disease pathogenesis has not been fully elucidated. The major objective of this conference is to accelerate the study of 3D genome organization; particularly with regard to gene regulation and human disease. The program will highlight recent technological advances, such as omics-based and imaging-based technologies, as well as discuss emerging concepts of chromatin organization and its role in cancer and other human diseases. Finally, the conference program will provide workshops and tutorials on the latest computational tools and data resources for 3D genome analysis. Because epigenetic processes such as chromatin remodeling and DNA methylation are intimately linked to the 3D genome architecture, this conference is jointly held with the Keystone conference on “Epigenetics and Human disease,” further contributing to the goal of stimulating cross-disciplinary interactions among researchers from the genomics, epigenomics, computational biology, cell biology and molecular biology fields.