Advancing Epigenetics Towards Systems Biology

Special Review Issue: The Dynamic Nucleus

Residing in the physical heart of the cell, the nucleus has now fully shed its once one-dimensional reputation as the repository for genetic information and steady supplier of messages to the cytoplasm. This sea change toward a more dynamic view of nuclear biology has been led by a revolution in our understanding of genomes, regulatory elements, epigenetic modifiers, and nuclear spatial organization, which has enabled the examination of the interplay of these factors both genome wide and at individual loci.

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