An ambitious EC-funded research initiative on epigenetics advancing towards systems biology 134

Institute of Molecular Biology (IMB), Mainz, Germany

Epigenetic Regulation of Epithelial to Mesenchymal Transition

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A key feature of progressive solid tumors is the acquisition of potential to invade other tissues to form metastatic lesions at distant sites by activating epithelial-mesenchymal transition (EMT) program. We aim to understand how epigenetic mechanisms contribute to the transcription reprogramming underlying EMT and how signaling pathways influence chromatin-mediated gene regulation during this process. To address these questions, the lab employs a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined cellular models.

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Latest publications

Computational Challenges in Modelling Gene Regulatory Events.

27390891 – 2016-07-09
Transcription 2016 Jul 8;:0
Pataskar A, Tiwari VK

The transcriptome of mouse central nervous system myelin.

27173133 – 2016-05-14
Sci Rep 2016 May 13;6:25828
Thakurela S, Garding A, Jung RB, Müller C, Goebbels S, White R, Werner HB, Tiwari VK

TOX3 regulates neural progenitor identity.

27080130 – 2016-04-16
Biochim Biophys Acta 2016 Apr 11;1859(7):833-840
Sahu SK, Fritz A, Tiwari N, Kovacs Z, Pouya A, Wüllner V, Bora P, Schacht T, Baumgart J, Peron S, Berninger B, Tiwari VK, Methner AView all their publications